@article {1039091,
	title = {Dissipative particle dynamics simulations for biological tissues: rheology and competition},
	journal = {Physical Biology},
	volume = {8},
	number = {2},
	year = {2011},
	note = {
	No free full text found

},
	abstract = {
	In this work, we model biological tissues using a simple, mechanistic simulation based on dissipative particle dynamics. We investigate the continuum behavior of the simulated tissue and determine its dependence on the properties of the individual cell. Cells in our simulation adhere to each other, expand in volume, divide after reaching a specific size checkpoint and undergo apoptosis at a constant rate, leading to a steady-state homeostatic pressure in the tissue. We measure the dependence of the homeostatic state on the microscopic parameters of our model and show that homeostatic pressure, rather than the unconfined rate of cell division, determines the outcome of tissue competitions. Simulated cell aggregates are cohesive and round up due to the effect of tissue surface tension, which we measure for different tissues. Furthermore, mixtures of different cells unmix according to their adhesive properties. Using a variety of shear and creep simulations, we study tissue rheology by measuring yield stresses, shear viscosities, complex viscosities as well as the loss tangents as a function of model parameters. We find that cell division and apoptosis lead to a vanishing yield stress and fluid-like tissues. The effects of different adhesion strengths and levels of noise on the rheology of the tissue are also measured. In addition, we find that the level of cell division and apoptosis drives the diffusion of cells in the tissue. Finally, we present a method for measuring the compressibility of the tissue and its response to external stress via cell division and apoptosis.

},
	url = {http://iopscience.iop.org/article/10.1088/1478-3975/8/2/026014/meta;jsessionid=08ECBC1924A359907E71FF701F5725BD.c2.iopscience.cld.iop.org},
	author = {Markus Basan and Jacques Prost and Joanny, Jean-Fran{\c c}ois and Jens Elgeti}
}
